Augmentation of Growth Hormone Secretion after Testosterone Treatment in Boys with Constitutional Delay of Growth and Adolescence: Evidence against an Increase in Hypothalamic Secretion of Growth Hormone-Releasing Hormone
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منابع مشابه
Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment.
Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children.
متن کاملPulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance.
Growth hormone (GH) secretion is regulated by GH-releasing hormone (GHRH), somatostatin, and possibly ghrelin, but uncertainty remains about the relative contributions of these hypophysiotropic factors to GH pulsatility. Patients with genetic GHRH receptor (GHRH-R) deficiency present an opportunity to examine GH secretory dynamics in the selective absence of GHRH input. We studied circadian GH ...
متن کاملGrowth hormone releasing hormone or growth hormone treatment in growth hormone insufficiency?
Sixteen prepubertal children who were insufficient for growth hormone were treated with growth hormone releasing hormone (GHRH) 1-40 and GHRH 1-29 for a mean time of nine months (range 6-12 months) with each peptide. Eleven children received GHRH 1-40 in four subcutaneous nocturnal pulses (dose 4-8 micrograms/kg/day) and eight (three of whom were also treated with GHRH 1-40) received GHRH 1-29 ...
متن کاملPhysiology of Growth Hormone Secretion
Growth hormone (GH) is secreted in a pulsatile fashion from the anterior pituitary gland. The synthesis and the secretion of GH are regulated mainly by two hypothalamic neuropeptides, the growth hormone-releasing hormone (GHRH) and somatostatin. A wide variety of physiologic and hormonal factors exert an effect on GH secretion. This paper will review physiology of GH secretion and the factors t...
متن کاملFasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
Studies in man have shown that the episodic release of growth hormone (GH) is infrequent and erratic, and unlike that in the rat does not appear to have discernible ultradian periodicities. However, these observations in nonfasted subjects may be invalid since mixed nutrients have unpredictable effects on GH release. Moreover, in the fed state basal GH levels are frequently undetectable, thus r...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2004
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2003-031948